To study the effect of age and BMI on markers of ovarian reserve in Indian women with primary infertility of age >35 years.

Dr.Shachi Shukla

Volume : V, Issue : VI, June - 2016

To study the effect of age and BMI on markers of ovarian reserve in Indian women with primary infertility of age >35 years.

Dr. Shachi Shukla

Abstract :

 Objective:–To study the effect of age and BMI on transvaginal USG and hormonal markers of ovarian reserve and to correlate USG markers with hormonal markers. Methodology: Fifty women with primary infertility of age >35 years having regular monthly cycles and no history of ovarian surgery were included in this cross–sectional study conducted from December 2010 until July 2011 in SMS Medical College. A transvaginal ultrasound to find out ovarian volume and antral follicles (AFC) and; blood tests for serum Follicle Stimulating Hormone (s.FSH) & serum. AntiMullerian Hormone (s.AMH) were carried out between the third and fifth day of their menstrual cycle. Results: s.FSH increases with increasing age; and s.AMH, ovarian volume and antral follicle count decreases with increasing age (p value<0.05). No significant effect of BMI on s.FSH, s.AMH, ovarian volume and antral follicle count (p value > 0.05) was seen. There is highly significant negative correlation between s.FSH and ovarian volume & s.FSH and AFC.There is highly significant positive correlation between s.AMH and ovarian volume & s.AMH and AFC Conclusion:–Age has significant effect on s.AMH, s.FSH, ovarian volume and antral follicle count while BMI does not significantly affect these markers. S.FSH increases with decreasing ovarian volume and antral follicle count while s.AMH decreases with decreasing ovarian volume and antral follicle count.