IJSR - International Journal of Scientific Research

Dr. Luna Kuli; Dr. (Mrs.) Chinmoyee Deori

Volume : VIII, Issue : VIII, August - 2019

TO STUDY THE TOPICAL ANALGESIC ACTIVITY OF HYDROETHANOLIC EXTRACT OF LEAVES OF CODIAEUM VARIEGATUM IN ANIMAL MODEL

Dr. Luna Kuli, Dr. Mrs. Chinmoyee Deori

Abstract :

The present study was aimed at evaluation of topical analgesic activity of the leaves of Codiaeum variegatum. All the animals were divided into four groups (n=5).Group 1 received Simple ointment topically only, Group 2 received the standard drug Methyl salicylate ointment 30 % topically, Group 3 received HEECV 2% w/w topically and Group 4 received HEECV 4% w/w topically. The first test to assess the topical analgesic acitivity was by Formalin induced paw licking test. Values are expressed as mean ± SEM. Statistical differences in mean were analyzed using one way ANOVA (analysis of variance) followed by Dunnett’s test. p<0.05 was considered significant. The second test to assess the topical analgesic activity was by Hot Plate Analgesiometer. The data were expressed as mean ± SEM. Difference between the experimental groups were statistically evaluated by one way analysis of variance (ANOVA) followed by Dunnett’s test. The level of significance was at p < 0.05.