To study the treatment comparison of salmeterol with fluticasone combination and formoterol with fluticasone combination in the management of persistent asthma

Aradhana Sharma; Hemant Tiwari

Volume : VII, Issue : IV, April - 2018

To study the treatment comparison of salmeterol with fluticasone combination and formoterol with fluticasone combination in the management of persistent asthma

Aradhana Sharma, Hemant Tiwari

Abstract :

Background:–The object of this study wastreatment comparison of salmeterol with fluticasone combination versus formoterol with fluticasone combination in the management of persistent asthma.

Material and methods::–This was a randomized, prospective, open–label study conducted in 50 patients of moderate persistent onchial asthma after taking informed consent.After simple randomization patients were enrolled in group–1 and group–2 and compared the effects of 2 weeks of treatment ofsalmeterol, 50 �g with fluticasone propionate 100�g twice daily and formoterol, 6�g with fluticasone propionate 100 �g twice daily .

Result:–Based on findings of this study it was observed that evening mean PEF in group 1 & 2 (38.04� 22.34,32.92�39.16 respectively) was statistically significant (P<0.05) as well asmorning mean PEF in group 1&2 (31.92�15.12, 25.64 � 14.6) was also statistically significant (P<0.05) . The mean difference of FEV1 % predicted in group–1 and group–2 was 1.41 � 5.67 which was

not statistically significant (p >0.05) as well as the mean difference of Evening and morning PEFin group–1 and group–2 was also not statistically significant (p >0.05).

Conclusion:–

We conclude that the long–acting �2–agonist and inhaled cortico–steroid combinations, formoterolwith fluticasone propionate andsalmeterol with fluticasone propionate improve morning and evening PEF, but without any significant difference in efficacy between the two combinations.