Treatment of adult onset multifocal single system Langerhans cell histiocytosis using single agent induction chemotherapy followed by maintenance oral Etoposide and External beam Radiotherapy: a case report.

Dr. Sreyes Ravi; Dr. Rajib Bhattacharjee

Volume : V, Issue : VI, June - 2016

Treatment of adult onset multifocal single system Langerhans cell histiocytosis using single agent induction chemotherapy followed by maintenance oral Etoposide and External beam Radiotherapy: a case report.

Dr. Sreyes Ravi, Dr. Rajib Bhattacharjee

Abstract :

 Adult onset Langerhans cell Histiocytosis is a rare disease that has a prolonged and relatively benign course compared to its more common juvenile–onset variant. Lack of consensus in limited multi–centric trials and treatment guidelines, particularly in the multisystem and multifocal single system variants need further assessment. Choosing a disease limiting chemotherapeutic drug regimen with minimal adverse effects is therefore, the need of the hour. Our endeavour was to replicate the success of monotherapy with Etoposide in children as seen in previously published case reports, in a patient with adult onset multifocal osseous Langerhans Cell Histiocytosis.