TWO HOURS PLASMA CONCENTRATION OF RIFAMPICIN IN PATIENTS OF NEWLY DIAGNOSED PULMONARY TUBERCULOSIS WITH AND WITHOUT DIABETES MELLITUS ON ANTI TUBERCULOSIS

Dr Dhruve Soni; Dr Sunil Kumar Mathur

Volume : IX, Issue : II, February - 2020

TWO HOURS PLASMA CONCENTRATION OF RIFAMPICIN IN PATIENTS OF NEWLY DIAGNOSED PULMONARY TUBERCULOSIS WITH AND WITHOUT DIABETES MELLITUS ON ANTI TUBERCULOSIS

Dr Dhruve Soni, Dr Sunil Kumar Mathur

Abstract :

Aim To estimate and compare rifampicin C2hr concentration in newly diagnosed pulmonary TB patients with and without DM on anti–tuberculosis therapy. Materials and methods: A cross–sectional study was done on 54 newly diagnosed pulmonary TB patients with and without DM on anti–TB drug therapy as per RNTCP. Sample was collected 2 hours post dose administration. Separated plasma was stored in liquid nitrogen until the analysis. Estimation of rifampicin concentration was done using HPLC. Result: Rifampicin plasma levels at 2 hours post drug administration (C2hr) were below reference ( ≥ 8�g/ml) in 24(100%) of diabetics and 23(77%) of non–diabetics. The mean Rifampicin Plasma C2hr � SD of diabetic TB patients was significantly lower than the non–diabetic TB patients with values of 3.52�0.96 and 5.79�1.73 �g/ml. Negative correlation was seen between RBS mg/dl and rifampicin plasma levels in diabetic and non–diabetic TB patients with Pearson correlation coefficient (r) of –0.74, p–value < 0.01 and –0.53, p–value < 0.01 respectively. Conclusion: Plasma levels of rifampicin were below reference in all of the diabetics and most of non–diabetic TB patients. Higher doses of rifampicin may be required to achieve therapeutic concentration for TB therapy. Therapeutic drug monitoring should be considered for TB therapy in patients of TB with DM as comorbidity.