Two interesting cases in The Spleen: A less studied organ!

Dr. Shilpi Sahu; Dr. Ujwala Maheshwari; Dr. Reeta Dhar; Dr. Reenal Patel

Volume : III, Issue : XII, December - 2014

Two interesting cases in The Spleen: A less studied organ!

Dr. Shilpi Sahu, Dr. Ujwala Maheshwari, Dr. Reeta Dhar, Dr. Reenal Patel

Abstract :

The spleen, is by nature, a bloody organ. Hypersplenism (dysplenism) refers to the excessive destruction of blood cells by the spleen, resulting in cytopenias of one or more blood cell lines. Hypersplenism may result from abnormalities inherent in the blood cells themselves or may be attributable to the increased sequestration of blood cells. Hypersplenism is of great clinico-pathological importance because it is the only major functional abnormality of the spleen, and it is the most frequent indication for splenectomy1. We report two interesting cases of hypersplenism with fiocongestive splenomegaly secondary to sickle cell disease and noncirrhotic portal hypertension (NCPH). The histopathological features of congestion and fiosis of red pulp, sickled red cells in the sinusoids and gamna-gandy bodies were diagnostic of sickle cell disease in the first case whereas a fiocongestive spleen along with only gamnagandy bodies and clinical correlation of portal vein thrombosis was diagnostic of splenomegaly secondary to NCPH.