Upper gastrointestinal tract findings and prevalence of Helicobacter.pylorii in HIV positive patients

Dr.M.Kannan; Dr.R.Ramani; Dr.E.Kandasamy Alias Kumar

Volume : VIII, Issue : III, March - 2019

Upper gastrointestinal tract findings and prevalence of Helicobacter.pylorii in HIV positive patients

Dr. M. Kannan, Dr. R. Ramani, Dr. E. Kandasamy Alias Kumar

Abstract :

Back ground :H.pylori affects 50% of population world wide. Whether immune deficiency plays a part in its incidence has been debated in literature. Prevalence of H. pylori in HIV positive patients were studied and compared to healthy individuals and literature published. AIMS: l. To study the prevalence of Hpylori in HIV positive patients, 2.To study the prevalence in relation to CD4+Tcell counts. 3.To compare the prevalence in HIV patients with controls and world literature.4,To study the gastrtc histologyin HIVpositives. MATERIALS & METHODS: Cross sectional study . H1V patients attending Department of Medical Gastroenterology, Government Rajaji Hospital, Madurai from January 2017 to January 2018 were divided into 4 groups, depending upon their CD4+T cell counts. Detailed physical examination. blood biochemistry, & endoscopy was done: HPE & RUT for H pylori. Controls included were H1V negative patients. RESULTS: 101 H1V patients in the age group 19 – 70 yrs included 68 males and 33 females 16 Patients with CD4 counts500 were seen. Hpylori was seen in 38% of HIV patients VS 77.9%, of controls. H pylorii was seen in 18.8% of CD1 group, 27,3% of CD2 , 39% of CD3 & CD4 groups. Histology of HIV posit vey and controls, showed, body gastritis in 55.4% vs 594% , lymphoplasmocytic infiltration in 4% vs 9.4%, adenocarcinoma % vs 1%, intestinal metaplasia in 2% vs 1%, and normal histology in 37% vs 29.2% in patients with CD4+T cell counts >500 had abnormal HPE in 72% vs 31% in patients with CD4+T cell <100. CONCLUSIONS: I. There is decreased positivity of H.pylori in HIV positive patients when compared to HIV negative controls as reportcd world wide. 2. H pylori prevalence was lower when CD4+T cell counts were lower.