Volume : VII, Issue : XII, December - 2018

USE OF PHENYTOIN IN WOUND HEALING: A REVIEW

Mohammed Hareesul Khaliq Waseehuddin

Abstract :

 Phenytoin (Dilantin or Diphenlhydantion), a Hydantoin derivative is a highly efficacious and widely prescribed Anticonvulsant agent and an Antiarrhythmic agent in the treatment of Grand mal and Psychomotor epilepsy. In 1937, Phenytoin was introduced into the therapy for effective convulsive disorder with common side effects being Gingival hyperplasia and Coarsening of the facies. In Dermatology, due to its stimulatory effect on the connective tissue Phenytoin is used in the treatment of wound healing in the pathological conditions such as diabetic ulcer which affects approximately  15% of diabetic individuals, Decubitus ulcer which is also known as Bed sore or Pressure ulcer, Epidermolysis bullosa and Chronic leg ulcer. The mechanism of action by which Phenytoin exerts its effect is that it increases gene expression of the platelet–derived growth factor B chain in macrophages and monocytes. Healthy granulation tissue develops earlier. The Common side effects of Phenytoin which occurs due to its long term use are Gingival Hyperplasia, Coarsening of the facies, thickening of the scalp and face and Enlargement of the lips.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

USE OF PHENYTOIN IN WOUND HEALING: A REVIEW , MOHAMMED HAREESUL KHALIQ WASEEHUDDIN , INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7|Issue-12| December-2018

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