Use of t–ALP in diagnosis of Mineral Bone Disease in CKD patients on dialysis

Dr. Babita Bansal; Dr. Anupinder Thind; Dr. Deepak Kumar Agrawal; Dr. Jaspreet Takkar

Volume : IX, Issue : II, February - 2020

Use of t–ALP in diagnosis of Mineral Bone Disease in CKD patients on dialysis

Dr. Babita Bansal, Dr. Anupinder Thind, Dr. Deepak Kumar Agrawal, Dr. Jaspreet Takkar

Abstract :

In patients of Chronic Kidney Disease (CKD), bone histology is routinely employed for the precise assessment of Mineral Bone Disease (MBD). The search for reliable biochemical bone parameters has been ongoing. Estimation of t–ALP has been used as main biochemical indicator in this cross–sectional observational study on dialysis patients. Biochemical analysis of total alkaline phosphatase & intact parathormone of all cases were done using fully automated equipments. To see the association among different patterns of MBD, statistical tests like Chi–square and ANOVA were used. The statistical analysis with χ2 testing of the results revealed that MBD is significantly associated with t–ALP level.The present study does not accept the null hypothesis and suggests that there is a statistically significant association of t–ALP levels with bone mineral disease (altered parathormone levels) for CKD patients on haemodialysis.