USEFULNESS OF VENOUS BLOOD GAS ANALYSIS TO DETERMINE ACID–BASE STATUS IN ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Sadariya Bhavesh R; Hariom Sharma; Sahema Shaikh; Mittal Panchal

Volume : III, Issue : VII, July - 2014

USEFULNESS OF VENOUS BLOOD GAS ANALYSIS TO DETERMINE ACID–BASE STATUS IN ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Sadariya Bhavesh R, Hariom Sharma, Sahema Shaikh , Mittal Panchal

Abstract :

Background: Chronic obstructive pulmonary disease (COPD) is associated with greatest morbidity and mortality, worldwide. Blood gas analysis is required to know acid-base status of the body in patients of acute exacerbation of COPD. Routinely arterial blood obtained by arterial puncture is used for blood gas analysis. It has been shown that venous blood can be used in place of arterial blood for blood gas analysis. The aim of present study was to see the changes in acid base status of the body in AECOPD patients by using venous blood for blood gas analysis. Methods: This study included previously diagnosed 100 patients of acute exacerbation of chronic obstructive pulmonary disease and 100 healthy

subjects. VBG sample was taken from each patient analyzed for pH, PCO₂, HCO₃^-, PO₂ and SO₂. Results: The mean � SD values for pH, PCO₂and HCO₃^- in AECOPD patients were 7.36 � 0.1, 53.31�18.62 mmHg and 29.21�8.78 mmol/L, respectively. In healthy controls, the mean � SD values for pH, PCO₂and HCO₃^- were 7.39�0.04, 46.02�6.7 mmHg and 28.3�4.1 mmol/L. Conclusion: Venous values of pH were slightly lower while venous values of PCO₂ and HCO₃^- were slightly higher in AECOPD patients as compared to the healthy subjects showed that AECOPD patients were in respiratory acidosis state