Volume : III, Issue : VI, June - 2014

Uses of stem cells in treatment of experimentally induced diabetes mellitus in dogs

Oday. K. Luaibi, Mohammad. M. Zenad, Abdul Majeed A. Hammadi, Saleem. A. Hasso

Abstract :

The current study aimed to highlight the ability of using differentiated stem cells in treatment of experimentally induced diabetes mellitus in dogs. Twenty native local male dogs aged 4-6 months were divided equally into four groups: Group I was control (left without any treatment), groups II, III, and IV were injected a single dose of alloxan (65 mg / kg wt) for inducing diabetes mellitus. Group II left as diabetic control (not treated), group III was given intravenous single dose of (1 ml/Kg wt) of cell free culture media at 10 days post alloxan administration, simultaneously group IV was administered by the same route autologous differentiated mesenchymal stem cells into insulin producing cells as a single dose of 2.5×106 cells/ml/Kg BW. The result showed typical clinical signs of diabetes mellitus, observed three days post alloxan injection and at the same time significant (P≤ 0.05) increase of blood glucose levels were recorded, these levels continued in elevation for 73 days in both groups II and III post alloxan injection, whereas significant (P≤ 0.05) lowering of blood glucose levels noted 4 days post cellular therapy, the gradual decline of glucose levels continued to 63 days. Conclusively the use of differentiated mesenchymal stem cells is an encouraging step in the treatment of diabetes mellitus and gives a glimmer hope to diabetic patients.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Oday. K. Luaibi, Mohammad.M.Zenad, Abdul-Majeed A. Hammadi, Saleem.A. Hasso Uses of Stem Cells in Treatment of Experimentally Induced Diabetes Mellitus in Dogs International Journal of Scientific Research, Vol.III, Issue.VI June 2014

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