Utility of Multiparametric 3 T MRI in Grading of Gliomas

Dr. Gaurav Raj; Dr. Manish Deodhar; Prof. Ragini Singh; Dr. Abhishek Chauhan; Dr. D.K. Singh; Prof. Nuzhat Husain

Volume : VI, Issue : II, February - 2017

Utility of Multiparametric 3 T MRI in Grading of Gliomas

Dr. Gaurav Raj, Dr. Manish Deodhar, Prof. Ragini Singh, Dr. Abhishek Chauhan, Dr. D. K. Singh, Prof. Nuzhat Husain

Abstract :

Intracranial gliomas are extremely heterogeneous in terms of imaging appearance. In this study, the role of multiparametric MRI for the characterization and grading of CNS gliomas has been explored. 52 patients underwent a comprehensive MRI examination which included parameters derived from diffusion– weighted, diffusion tensor, dynamic contrast enhanced imaging and MR spectroscopy at a field strength of 3 T. 33 cases were subsequently proven to be gliomas on histopathology and the imaging parameters were correlated with histopathologic grading to determine optimal cut off values to differentiate high grade (grades III, IV) from low grade (grade I, II) gliomas. Combining multiple parameters obtained from advanced MRI techniques enabled preoperative grading of gliomas with high sensitivity and specificity.