WILMS TUMOR - A 10 YEAR INSTITUTIONAL REVIEW AT GMCH NAGPUR

DR.ASHOK KUMAR DIWAN; DR.SAURABH MESHRAM; Dr.Subeera Khan

Volume : VIII, Issue : IX, September - 2019

WILMS TUMOR - A 10 YEAR INSTITUTIONAL REVIEW AT GMCH NAGPUR

Dr. Ashok Kumar Diwan, Dr. Saurabh Meshram, Dr. Subeera Khan

Abstract :

BACKGROUND– Wilms tumor also known as nephroblastoma has multimodality treatment approach leading to good prognostic outcomes in this disease, still in India the overall survival is poor. Also,there is paucity of data about the epidemiology, pathology, treatment and prognosis of the disease from India, therefore we conducted a retrospective analysis of the multimodality treatment & report the outcomes of Wilms tumor at department of radiation oncology at GMCH Nagpur over 10 yrs MATERIAL AND METHODS– 104 clinico–radiologically and histopathologically proven patients registered of which 68 were evaluated for Demographic Data,Clinico–pathologic Profile, Treatment related data and Survival registered from 2007–2017 at the dept of radiation therapy and oncology GMCH Nagpur RESULTS– – Total 104 patients of which 53 were males (50.96%) and 51 were females (49.03%) with mean age at the time of diagnosis 4.4�0.84yrs. Radical Nephrectomy was performed in 62% of cases, 25% were metastatic & 13% came in locally advanced stage with poor general condition at the time of presentation. Favourable histology findings were found in 38 (56.71%) and unfavourable were 29 (focal + diffuse + CCK + RTK) (42.85%). 5 yrs overall survival rate stage I 90% stage II 80% stage III 75%stageIV 45%, the 5 yrs overall survival rate was found to be 74.25%. CONCLUSION– the children who presented at our institute came in late stages; most common presentation was in stage III followed by stage IV. The 5 year &10–year survival rate & event free survival rate was very low compared to the other studies. The probable reason for this may be due to the presentation of patients in late stages and poor general condition causing difficulty in delivering the optimum treatment