Volume : VI, Issue : X, October - 2017

Working with CML: Knowing the disease.

Niyaz A Azad, Zafar A Shah

Abstract :

 Chronic myeloid leukemia (CML), also known as chronic myelogenous leukemia, is a type of cancer that starts in certain blood–forming cells of the bone marrow. In CML, a genetic change takes place in an early (immature) version of myeloid cells – the cells that make red blood cells, platelets, and most types of white blood cells (except lymphocytes). This hallmark physical change initiating CML is a reciprocal translocation involving two different genes i.e. ABL from chromosome 9 and BCR from chromosome 22 that leads to the emergence of a new abnormal fused or chimeric oncogene, BCR–ABL, on a changed chromosome 22, called the Philadelphia chromosome.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Niyaz A Azad, Zafar A Shah, Working with CML: Knowing the disease., INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-6 | Issue-10 | October-2017

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