A CLINICAL AND  BIOCHEMICAL STUDY OF SERUM PROTEIN PROFILES IN CASES OF OBSTRUCTIVE JAUNDICE

DR. D.KISHAN; DR. M.SRIDHAR

Volume : VI, Issue : IV, April - 2016

A CLINICAL AND BIOCHEMICAL STUDY OF SERUM PROTEIN PROFILES IN CASES OF OBSTRUCTIVE JAUNDICE

Dr. D. Kishan, Dr. M. Sridhar

Abstract :

1.Background; obstruction to the flow of bile can impair liver function in several ways . which included synthetic and excretory function of liver. Estimation of serum proteins is one of the methods of estimation of chronicity and severity of liver damage and predicts out come in such cases. 2. Methods; serum protein profiles of 40 patients with surgical jaundice was studied over a period of 18 months. Variations in protein concentrations due to malignant and benign causes were analysed mainly with regard to albumun, prothrombin time, total proteins globulins and A;G ratio. 3. Results; total serum proteins were decreasd in patients with obstructive jaundice due to any cause compared with normal population. Serum protein changes due to malignant obstruction is similar to benign cause of obstruction. 4. Conclusion; estimation of various serum protein changes in obstructive jaundice is very important as it may influence management of patients and predict outcome disease because significant changes in these indicates irreversible changes in liver which are associated with bad prognosis in obstructive jaundice.