Volume : IX, Issue : V, May - 2019

A CLINICAL STUDY OF BPH AND ITS MEDICAL MANAGEMENT WITH SPECIAL REFERENCE TO TAMSULOSIN

Dr. Protiva Probhakor, Dr. Bijoyananda Das

Abstract :

Introduction: Currently α1–adrenoceptor blockers are widely used as first–line therapy to improve lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). The aim of this study was to evaluate the efficacy of Tamsulosin in BPH patients with mild to moderate symptoms. Material and Methods: The present hospital based prospective interventional study was conducted in Department of Surgery and Urology Out–Patient Department, Assam Medical College and Hospital, Diugarh, during the time period of 1st June 2016 to 31st May 2017 and 49 cases of BPH with mild to moderate symptoms and prostate volume ≤30 cc were included in the study. All patients were administered Tamsulosin (0.4 mg) once daily for 3 months after obtaining ethical clearance and administering informed consent. The patients were followed up for changes in PVR, IPSS, IPSS–QoL, PV and S.PSA which were recorded and analyzed using appropriate statistical tools. Results: At the end of 1 month and 3 months, PVR (baseline 35.19±8.13 ml) was 19.1±4.47 ml and 16.67±3.51 ml, IPSS score (baseline 12.67±3.16) was 8.1±1.89 and 7.00±1.53, IPSS–QoL (baseline 4.45±0.84) was 2.69±0.54 and 2.08±0.44, change in PV was +0.34%, and 1.46% and S.PSA (baseline 1.9±1.1 ng/ml) was 1.8±1.0 ng/ml and 1.8±1.0 ng/ml respectively. However at the end of 3 months, 19 patients (38.7%) were administered Tamsulosin 0.4mg for 3 more months due to persistence of symptoms. In these patients at the end of 6 months PVR was 18.31±2.34 ml, IPSS was 7.00±1.29, IPSS–QoL was 2.0±0.47, change in PV was +8.79% and S.PSA was 2.4±0.9ng/ml. Conclusion: There is statistically significant improvement in PVR, IPSS and IPSS–QoL, although there is no effect on PV and S.PSA. Thus, Tamsulosin 0.4 mg can be used for effective relief of LUTS caused due to BPH in mild to moderate cases with PV ≤30 cc.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

A CLINICAL STUDY OF BPH AND ITS MEDICAL MANAGEMENT WITH SPECIAL REFERENCE TO TAMSULOSIN, Dr. Protiva Probhakor, Dr. Bijoyananda Das INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-5 | May-2019

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