IJAR - Indian Journal of Applied Research

Volume : VIII, Issue : V, May - 2018

Dr. Swetha Jain, Dr. B. Balachandrudu

Summary:

Background: Though hyperpigmentary disorders are common in India, few have studied the clinico–epidemiological

prole these disorders.

Aims: To study the clinical pattern of melasman in women, to evaluate the different etiological factors in hyperpigmentary disorders, to assess

the efcacy of glycolic acid peels (20 –30%) and TCA (10 –20%) and their respective side effects.

Material & Methods: A study was conducted on female patients with melasma disorders between January 2013 to January 2014. A proforma

containing detailed information on each patient was prepared according to the protocol designed for the study. Informed consent was taken from

all the patients included in the study. Patients with Melasma by method of randomization, were allocated alternately into groups A and B and

treated with Glycolic and TCA PEEL. Modied Masi score for melasma will be evaluated at the start of treatment and again at the end of three

months

Results: Total number of 315 patients with hyperpigmentary disorders of face attended our DVL OPD out of which 150 patients

presented with melasma of which 50 patients with melasma who satised our criteria were enrolled in the study. The most common

hyperpigmentary disorder affecting observed was melasma followed by post inammatory hyperpigmentation.The maximum incidence of

melasma was found in age group of 31–40 (64.00%) followed by 41–50 (20.00%) , 21–30(12.00%), 51–60 (4%).Mean age for presentation

of melasma was 37.7 years. The mean duration was 5.3 years. History of aggravating melasma with sun exposure was present in 28

patients and 22 patients gave no such association. Family history of melasma was positive in 18% of our patients .In our study 18 % of

patients gave a history of occurrence of melasma during pregnancy.The centrofacial pattern was observed in the majority of cases (58%)

followed by malar pattern was seen in 42% of the patients.On woods lamp examination the most common type was epidermal 40.00%

followed by indeterminate type 32.00%, mixed type was seen in 18 % and least incidence was seen in dermal 5 (10.00%).In our study

group A out of 25, greater than 75% improvement in modied MASI score that was seen in 3( 12.00%) 50–74% was seen in 5 (

20.00%, and 26–49% was seen 14( 56.00%), and less than 25% was seen 3 (12.00%)In group B out of 25 greater than 75%

improvement of masi score is seen in 1 patient (4.00%), 50–74% was seen 14 (56.00%) , 26–49% was in 9 (36.00%,) and less than 25%

was seen 1( 4.00%).

Conclusions: Our study is a detailed analysis of the clinico–etiological factors of melasma compare the efcacy of Glycolic and TCA peels

in melasma at a tertiary hospital