Volume : IX, Issue : I, January - 2019

A clinical study to evaluate the correlation of lipoprotein and Acute Coronary Syndrome

Dr Manish Dudhani, Dr Arvind

Abstract :

Background Indians have a high prevalence of coronary heart disease (CHD) in early age as compared to other ethnic groups. Risk factors associated with young acute coronary syndrome (ACS) patients differ from those in the elderly. Material &Method This case control study included 60 patients having ACS. Clinical features, risk factor profiles of these patients were studied and compared with 30 control patients having no history of ACS. Results Serum Lipoprotein was raised in both males and females ACS patients (p>0.05) i.e.Serum Lp(a) levels were not affected by gender of the patient. 71% of cases of ACS had significantly high Lp(a)(>30mg/dl) as compared to 23% in control cases (p value < 0.01).The mean serum Lp(a) level in cases of ACS was 45.96±24.07 which is significantly higher than control value of 23.7±8.46 (p value < 0.01). Lp(a) level were found to have a graded association with ACS, with increase of ACS incidence with higher values of Lp(a). High serum Lp(a) values were present in 87% (21/24) diabetic patients suffering from ACS which was significantly higher than non diabetic patients suffering from ACS 61% (22/36) (p value < 0.01). Conclusion In present study it was concluded that serum Lp(a) levels were significantly raised in ACS patients as compared to healthy controls(45.96 + 24.07, Vs. 23.7 + 8.46; p < 0.001). Serum Lp(a) levels had a graded association with ACS and its effects were significantly increased in presence of Diabetes Mellitus(high blood sugar) , high BMI(>25 kg/m2 ), high LDL–cholesterol and high TOTAL–/HDL–cholesterol ratio (>3.5).Thus high serum Lp(a) >30 mg/dl is an independent risk factor for ACUTE CORONARY SYNDROME.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

A CLINICAL STUDY TO EVALUATE THE CORRELATION OF LIPOPROTEIN AND ACUTE CORONARY SYNDROME, Dr Manish Dudhani, Dr Arvind INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-1 | January-2019

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