A Clinicopathologic Comparison of Cyclin D1–Positive and Cyclin D1–Negative Lymphomas with Mantle Cell Morphology

El-Esawy . B. H; H.Osman; El Askary A

Volume : IV, Issue : VI, June - 2014

A Clinicopathologic Comparison of Cyclin D1–Positive and Cyclin D1–Negative Lymphomas with Mantle Cell Morphology

El Esawy . B. H, H. Osman, El Askary A

Abstract :

Background:. MCL has an aggressive and incurable clinical course and frequent T(11;14)(q13;q32) translocation. The aim of this study was to investigate the value of cyclin D1 expression in B&ndash; cell non Hodgkin lymphoma with mantle cell morphology &amp; study of clinico&ndash;pathological correlation. 171cases have been examined for lymphoma with MCL morphology from a viewpoint of cyclin D1 over expression, Using SPSS program. 138 cases (80.7%) showed positive nuclear staining for cyclin D1, while the remaining 33 (18.7%) were negative. The cyclin D1&ndash; positive group showed a higher age distribution (P .035), larger cell size (P.04), higher mitotic index (P .03) while the cyclin D 1 negative group showed significant CD 23 expression (P.003) Both cyclin D1&ndash; positive and &ndash;negative groups may represent different entities. Therefore, cyclin D1&ndash;positivity should be included as one of the standard criteria for MCL diagnosis and proper therapy.