A CLINICOPATHOLOGICAL STUDY OF COLORECTAL CARCINOMA WITH SPECIAL REFERENCE TO MUCIN CONTENT

Dr. Lucky Moni Duara; Dr. Uttam Konwar

Volume : VI, Issue : VII, July - 2016

A CLINICOPATHOLOGICAL STUDY OF COLORECTAL CARCINOMA WITH SPECIAL REFERENCE TO MUCIN CONTENT

Dr. Lucky Moni Duara, Dr. Uttam Konwar

Abstract :

Colorectal Carcinoma is the most common Gastrointestinal malignancy and is a major cause of morbidity and mortality. Mucin is one pathologic feature considered important for prognosis. Mucins are glycoproteins that are secreted specially by the goblet cells of the gastrointestinal tract. There are two types of mucins – neutral and acidic. In the present study an attempt was made to assess the colorectal carcinomas clinicopathologically with emphasis to age, sex, site, grading and to evaluate the mucin content in the tumor histochemically and to correlate the mucin content with the the histological grading. In the study H&E was used as a routine stain for the histological diagnosis and special stain PAS (Periodic Acid Schiff) for presence of mucin and AB/PAS (Alcian Blue/Periodic Acid Schiff) to differentiate neutral and acidic mucins. It was observed that there was a rising trend in young patients and that acid mucins were predominant in comparison to neutral mucin.