A Comparative Clinical Study of Dexmedetomidine and Fentanyl in Attenuating Stress Response during Laryngoscopy and Endotracheal Intubation

Dr. Sagar Rakesh Tyagi; Dr.Shikha Goyal

Volume : VIII, Issue : X, October - 2018

A Comparative Clinical Study of Dexmedetomidine and Fentanyl in Attenuating Stress Response during Laryngoscopy and Endotracheal Intubation

Dr. Sagar Rakesh Tyagi, Dr. Shikha Goyal

Abstract :

This study was designed to compare effect of dexmedetomidine and fentanyl on cardiovascular responses during intubation under general anesthesia. Sixty adult patients were randomly recruited to 2 groups of 30 each. Group D:Dexmedetomidine group(0.5mcg/kg diluted to 10ml NS). Group F:Fentanyl group (2mcg/kg diluted to 10ml NS). Heart rate, systolic & diastolic blood pressure were recorded prior to drug ,1 min after drug administration, at 30 sec,1,2,3, 5, 7 & 10 minutes after intubation. Side effects like adycardia, hypotension, nausea, shievering & desaturation also noted. Heart ratewas lower in group D at all time intervals. Systolic and diastolic BP was lower in group D from 30 sec after intubation till end of study (p≤0.05). Bradycardia was found in 2 patient in group D.We concluded that dexmedetomidine is more efficacious than fentanyl in attenuation of stress response during intubation period.