A COMPARATIVE STUDY BETWEEN DROPERIDOL AND GRANISETRON FOR PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING AFTER LAPAROSCOPIC CHOLECYSTECTOMY

Apoorwa N Kothari; Deepa Baskaran

Volume : VII, Issue : X, October - 2017

A COMPARATIVE STUDY BETWEEN DROPERIDOL AND GRANISETRON FOR PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING AFTER LAPAROSCOPIC CHOLECYSTECTOMY

Apoorwa N Kothari, Deepa Baskaran

Abstract :

Background: Post–operative nausea and vomiting (PONV) is a commonly observed undesirable consequence of laparoscopic cholecystectomy. Many pharmacological agents with varying effectiveness are investigated with none entirely effective in preventing PONV. This study was undertaken to compare the efficacy of granisetron and droperidol in reducing the incidence and severity of PONV after laparoscopic cholecystectomy.

Aims and Objectives: To compare the antiemetic efficacy of droperidol and granisetron following laparoscopic cholecystectomy, study the incidence of PONV and observe for side–effects in both the groups.

Materials and methods: 60 patients posted for laparoscopic cholecystectomy were randomly allocated into 2 groups, each consisting of 30 patients. One group received 20mcgkg^–1Droperidol and the other group received 60mcg kg^–1Granisetron. Patients were assessed for first three hours and at 24hours postoperatively for presence and severity of PONV and any side effects.

Results: In droperidol group, 26 (86.7%) had no episodes of nausea at first two hours and 25 patients (83.3%) had no nausea at 24 hours postoperatively.

Two (6.7%) patient had severe nausea at 2^nd hour and 3^rd hour postoperatively.2 patients (6.7%) reported of vomiting at 24hours postoperatively.

In granisetron group, 27patients (90%) had no nausea at first two hours and 28 (93.3%) had no nausea at 24 hours postoperatively. No patients reported of severe nausea and vomiting in this group.

The incidence of nausea and vomiting in droperidol group (17%) was not significantly higher than the granisetron group (11%,p = 0.321).

Conclusion: Droperidol and Granisetron are safe and equally effective in reducing the incidence and severity of PONV after laparoscopic cholecystectomy.