A Comparative Study Between Epidural Buprenorphine and Epidural Nalbuphine in Major Gynaecological Surgeries

Mallika Datta; Suman Chattopadhyay

Volume : VIII, Issue : I, January - 2018

A Comparative Study Between Epidural Buprenorphine and Epidural Nalbuphine in Major Gynaecological Surgeries

Mallika Datta, Suman Chattopadhyay

Abstract :

Epidural anaesthesia is an effective method of anaesthesia and postoperative analgesia. This randomized control trial compares block characteristics and post operative duration of analgesia of a single dose of two opioids with partial agonist–antagonist properties (buprenorphine 0.3 mg and nalbuphine 10 mg, equivalent to morphine 10 mg) added to 15 ml of epidural levo–bupivacaine.

50 randomised patients received either epidural buprenorphine or nalbuphine adjuvants as group B or Group N of 25 patients each. The demographic profile, operation type and surgical duration were similar between the groups as well as the onset of both the sensory and motor blockade. The incidences of side–effects were similar between the two groups. However, the duration of analgesia of buprenorphine group was significantly greater compared to the nalbuphine group (16.26±2.4 vs 6.46±1.4 hour; p<0.01). To conclude, buprenorphine has significantly greater analgesic property as compared to nalbuphine when used as an adjuvant for epidural anaesthesia. (150 words)