IJAR - Indian Journal of Applied Research

Dr. Petla Rama Krishna; Dr. C. Surya Narayana

Volume : V, Issue : V, May - 2015

A COMPARATIVE STUDY OF ATTENUATION OF STRESS RESPONSE TO INTUBATION FOR INTRACRANIAL SURGERIES WITH LABETALOL, NITROGLYCERINE AND XYLOCARD

Dr. Petla Rama Krishna, Dr. C. Surya Narayana

Abstract :

INTRODUCTION: The pressure response, which was part of a huge spectrum of stress response, results from the increase in sympathetic and sympathoadrenal activity. A comparison between labetolol, ntroglycerine and xylocardl in suppressing the pressor response for intubation in intracranial surgeries was studied. OBJECTIVE: This study was done to compare the effectiveness of labetalol,nitroglycerine and xylocard in attenuating the pressor responses associated with laryngoscopy and endotracheal intubation in groups belonging to normotensive ASA grade 1, 2 risk surgical patients. MATERIAL: The study was carried out on 80 patients belonging to ASA grade I and II, aged 18 to 45 years, including either gender, scheduled for neuro surgical procedures under general anesthesia. They were divided into 4 groups of 20 patients each, which were receiving normal saline, Labetolol, xylocard and NTG respectively. RESULT: It was concluded that labetalol was more effective in preventing the rise in heart rate and rate pressure product to larngoscopy and intubation than xylocard and nitroglycerine Nitroglycerine was more effective than labetalol and xylocard in attenuating the rise in systolic ,diastolic and mean arterial pressures.