A Comparative study of effects of dexmedetomidine and lidocaine in alleviating  propofol injection pain in a tertiary care centre.

Dr Joydeep Debnath; Dr Anupam Chakrabarti

Volume : VII, Issue : VIII, August - 2017

A Comparative study of effects of dexmedetomidine and lidocaine in alleviating propofol injection pain in a tertiary care centre.

Dr Joydeep Debnath, Dr Anupam Chakrabarti

Abstract :

Objective: Diisopropyl group containing intravenous induction agent Propofol is a commonly used drug for general anesthesia. Propofol, can irritate the skin, mucous memane, and venous intima. The main drawback is the pain on injection.We have compared the analgesic effects of lidocaine, dexmedetomidine, in reducing propofol injection pain.

Materials and Methods: Following the approval of the hospital’s Ethics Committee, 140 adult patients of both sexes [aged 18–60 years, American Society of Anesthesiologists (ASA) I and II] were divided into two groups (n = 70) 0.25 mg/kg of dexmedetomidine, and 0.5 mg/kg of lidocaine diluted in 5 ml of saline injected just before the propofol injection in the same hand. The propofol injection pain was assessed according to the McCrirrick and Hunter scale.

Result: Among dexmedetomidine & lignocaine both reduces pain on propofol injection, even though lidocaine is better than dexmedetomidine.

Conclusion: Pretreatment with 0.25 μg/kg of dexmedetomidine with venous occlusion for one min is also as effective as IV lidocaine pretreatment in alleviating propofol injection pain, though lidocaine is better than dexmedetomidine.