A COMPARATIVE STUDY OF EFFICACY OF TOPICAL PHENYTOIN VERSUS CONVENTIONAL WOUND CARE IN DIABETIC ULCERS

Dr. A. Anusha; Dr. M.V.Reddy; Dr. P. Vijayendra

Volume : VIII, Issue : X, October - 2018

A COMPARATIVE STUDY OF EFFICACY OF TOPICAL PHENYTOIN VERSUS CONVENTIONAL WOUND CARE IN DIABETIC ULCERS

Dr. A. Anusha, Dr. M. V. Reddy, Dr. P. Vijayendra

Abstract :

Introduction:Diabetic ulcer is a significant healthcare problem with its healing depending on many factors. Many agents have been tried in wound healing and one such agent is phenytoin.The aim of this prospective comparative study was to compare the efficacy of topical phenytoin with conventional wound dressingsin the healing of diabetic ulcers.

Patients and methods: This prospective comparative study included fifty patients,with 25 patients in each group. The patients were compared in terms of number of days required for healing, rate of granulation tissue formation, effect on bacterial load and skin graft up take.

Observations and results: Both the groups were comparable in terms of patient demographics.Rate of granulation tissue formation was more rapid in phenytoin group with a mean of 85.21% as compared to conventional moist dressing groupwith a mean of 70.32%.Hospital stay was significantly reduced in phenytoin group with a mean of 30.04days compared to conventional moist dressing group with a mean of 45.10 days. Percentage of graftuptake is more in phenytoin group with a mean of 91.78% compared to conventional moist dressing group with a mean of 75.48%.

Conclusion: Rate of granulation tissue formation,overall graft uptake, patient compliance and overall hospital stay were better in thetopical phenytoin dressing group. Thus, topical phenytoin moist wound dressing can be considered as asuperior option in the management of diabetic ulcers.