A COMPARATIVE STUDY OF FENTANYL AND NALBUPHINE ON HAEMODYNAMIC CHANGES DURING INTUBATION IN GERIATRIC PATIENTS

DR SK AHADUL ISLAM; DR SUJATA DALAI

Volume : X, Issue : II, February - 2020

A COMPARATIVE STUDY OF FENTANYL AND NALBUPHINE ON HAEMODYNAMIC CHANGES DURING INTUBATION IN GERIATRIC PATIENTS

Dr Sk Ahadul Islam, Dr Sujata Dalai

Abstract :

Objective: The haemodynamic changes associated with laryngoscopy and endotracheal intubation are due to mainly sympathoadrenal reflex and release of norepinephrine, epinephrine. So, laryngoscopy and intubation is a challenge to anaesthesiologist with obtundation of pressor response in these patients. Methods: Seventy patients were randomly selected matching the inclusion criteria and they were randomly allocated in either of two groups (n=35). Group F was given i.v. fentanyl 2mcg/kg and group N given i.v. Nalbuphine 0.2 mg/kg five min before intubation. we excluded the patient whose laryngoscope and intubation time was exceeded 15 secs. Results: The SBP and DBP,MAP and mean heart rate of the patients of group–N was significantly higher than that of group–F after drug administration to 5 minute after intubation (p<0.01). Conclusion: Intravenous fentanyl (2mcg/kg) controls the stress response to laryngoscopy and intubation better as compared to i.v nalbuphine (0.2mcg/kg) in geriatric patients but the adverse effect profiles are more in fentanyl arm.