A COMPARATIVE STUDY OF GRANISETRON AND PALONOSETRON FOR PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING FOLLOWING LAPAROSCOPIC SURGERY

Dr.Murali Prabhakar; Dr.Manjusruthi Borra

Volume : V, Issue : III, March - 2015

A COMPARATIVE STUDY OF GRANISETRON AND PALONOSETRON FOR PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING FOLLOWING LAPAROSCOPIC SURGERY

Dr. Murali Prabhakar, Dr. Manjusruthi Borra

Abstract :

Context: Granisetron and Palonosetron for prevention of postoperative Nausea and Vomiting fol–lowing laparoscopic surgery. AIM: aim of our study was to Comparison Granisetron and Palonosetron for prevention of post–operative Nausea and Vomiting following laparoscopic surgery. Settings and Design: Sixty adults patients of class ASA I and II of either sex in age group between 20 to 70yrs, scheduled for elective laparoscopic surgeries were se lected for the study. Patients were randomly divided into two groups 30 each. Group ‘G’ : Granisetron group Group ‘P’ : Palonosetron group Materials and Methods: At the end of the surgery before extubation Group G patients re–ceived 40µg/kg of Inj. Granisetron and Group P patients received 0.075mg of Inj. Palonosetron slowly i.v over a period of 30 seconds Statistical Analysis Used: Comparibility of groups are analyzed by ANOVA followed by un paired ‘t’ test Chi–square test, fisher exact test.there was no significant difference between the two groups.(p > 0.05). Results: The incidence of nausea was significantly more with patients who received granisetron than when compared with patients who received palonosetron during delayed PONV period ( 12 – 48 hrs).No statistically significant difference is present between palonosetron group and grani–setron group for the prevention of vomiting both during early and delayed PONV period. Conclusion: We have observed that:Nausea and vomiting is more common in female patients undergoing Laparoscopic surgery.Over all complete response occurred in granisetron was 66.7% and Palonosetron group was 86.7%. Palonosetron is more effective than Granisetron in prevent–ing PONV upto 48 hrs (even upto 72 hrs in the study conducted by other authors).Palonosetron has less incidence of side effects as compared to granisetron.Use of rescue antiemetic is less with the Palonosetron as compared to granisetron.Palonosetron is more potent and long acting as compared to granisetron.