A Comparative Study of Nalbuphine with Butorphanol for immediate postoperative analgesia in lumbar spine surgeries.

Dr. Tushar Kumar; Dr. Mukesh Kumar; Dr. Prof. Ladhu lakra; Dr. Kundan Kumar; Dr. Reena Hansda; Dr. (Prof) Usha Suwalka

Volume : VIII, Issue : X, October - 2018

A Comparative Study of Nalbuphine with Butorphanol for immediate postoperative analgesia in lumbar spine surgeries.

Dr. Tushar Kumar, Dr. Mukesh Kumar, Dr. Prof. Ladhu Lakra, Dr. Kundan Kumar, Dr. Reena Hansda, Dr. Prof Usha Suwalka

Abstract :

Postoperative pain is acute pain and can aﬀect nearly every organ function and may adversely inﬂuence postoperative morbidity and mortality. Pharmacological management with intravenous opioids is a common, eﬀective and a well known method used to treat this pain. Our study aims at compå the analgesic eﬃcacy of nalbuphine and butorphanol as opioid analgesics for post operative pain relief for immediate postoperative period. Material and methods: double blind, randomized controlled clinical trial, 20 patients aged 18 to 60 years, ASA grade 1 or 2, posted for lumber spine surgery surgery under general anaesthesia. Patients were randomly allocated into 2 groups, Study design: Group N (Nalbuphine) and Group B (Butorphanol). Group N received 0.2 mg/kg of Nalbuphine hydrochloride whereas group B received 0.04 mg /kg of butorphanol , intravenously prior to induction of anaesthesia. Hemodynamic parameters, postoperative analgesia, time of rescue analgesia, respiratory depression, sedation scores and side eﬀects were studied. Pain assessed as VAS. Results: scores were not signiﬁcantly diﬀerent to start with (60 mins) immediate postop in both the groups (p= 0.76). They were lower in both Group B and Group N at 15, 30, 45,60, 75,90 and 105 mins. At 120 mins, there was no signiﬁcant diﬀerence between the mean VAS across both the groups. No signiﬁcant diﬀerences were seen in recovery from anaesthesia. No signiﬁcant side eﬀects of nausea, vomiting, and respiratory depression were noted. Excessive sedation were noted in group B which was significant( p = 0.036). Conclusion: both butorphanol and nalbuphine provide excellent analgesia in immediate post operative period except that butorphanol causes excessive sedation specially in elderly age group.