Volume : IX, Issue : VII, July - 2019

A COMPARATIVE STUDY OF RAMOSETRON AND GRANISETRON FOR PREVENTION OF POST OPERATIVE NAUSEA AND VOMITING IN PATIENTS UNDERGOING LAPAROSCOPIC GYNECOLOGICAL SURGERIES UNDER GENERAL ANESTHESIA

Dr Suchismita Pal, Dr Jayanta Bhattacharya

Abstract :

INTRODUCTION: Post–operative nausea and vomiting (PONV) is one of the most distressing and common complaint that patients have following general anesthesia. Laparoscopic gynecological surgery is associated with high incidence of post–operative nausea and vomiting. Granisetron is a selective competitive 5HT3 receptor agonist having both central and peripheral actions. Ramosetron is another 5HT3 receptor antagonist of newer generation with prolonged duration of action. This study compared the efficacy of prophylactic use of granisetron and ramosetron for prevention of PONV following laparoscopic gynecological surgery. METHODS: In a prospective randomised study, 80 adult females received either granisetron(2.5mg) or ramosetron(0.3mg) (N=40 in each group) by the intravenous route at the end of the surgery. The treatment groups were similar in patient characteristics, surgical procedures and anesthetic management. Observation was done upto 48 hours post–operative. RESULTS: Even though the incidence of nausea in the last 24 hours of observation was statistically significant in the ramosetron group vs granisetron (p=0.019) but the total response of 48 hours duration for both the groups were observed to be statistically insignificant (p=0.237). CONCLUSION: In conclusion, prophylactic therapy with Ramosetron is equally effective as prophylactic therapy with Granisetron for the prevention of PONV in laparoscopic gynecological surgery

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

A COMPARATIVE STUDY OF RAMOSETRON AND GRANISETRON FOR PREVENTION OF POST OPERATIVE NAUSEA AND VOMITING IN PATIENTS UNDERGOING LAPAROSCOPIC GYNECOLOGICAL SURGERIES UNDER GENERAL ANESTHESIA, DR SUCHISMITA PAL, DR JAYANTA BHATTACHARYA INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-7 | July-2019

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