A Comparative study of the Therapeutic Efficacy of Itraconazole versus Terbinafine in the treatment of Tinea corporis and Tinea cruris infection.

Volume : VIII, Issue : VI, June - 2018

Dr. Sumeet Pal Saini, Dr. Anil Kumar Mehta, Dr. J. S Bist

Dermatophytosis is a disease condition characterized by the infection of keratinized tissues such as the epidermis, hair

and nails. We planned a comparative study to provide the insight into the therapeutic efficacy of Itraconazole and

Terbinafine, the two preferred drugs for the treatment of T. corporis and T. cruris.

METHOD– Recruited subjects were assigned alternatively between 2 groups each to receive Itraconazole 100 mg OD or Terbinafine 250mg OD

for 2 weeks. Therapeutic efficacy was evaluated at completion of therapy i.e at 2nd and 4th weeks. Mycological samples (skin scrapings) were

examined by prepå 10% KOH mounts.

RESULTS– The patients with no clinical signs or symptoms with negative mycology (effective therapy) were 69 in Itraconazole group and 55 in

Terbinafine group. The patients who had ineffective cure (improvement and treatment failure) were 26 in Itraconazole group and 39 in Terbinafine

group showing Itraconazole to be a better drug.