IJAR - Indian Journal of Applied Research

Dr. Durgaprasad Boddepalli

Volume : IX, Issue : VI, June - 2019

A comparison of efficacy, safety and cost–effectiveness between combination therapy of topical nadifloxacin versus clindamycin with benzoyl peroxide in treatment of acne vulgaris.

Dr. Durgaprasad Boddepalli

Abstract :

Background: Acne vulgaris is a dermatological disorder in which anti microbials, keratolytics are commonly prescribed in the treatment of acne. Aim: The present study was undertaken with the aim of compå the efficacy, safety, cost–effectiveness of combination of topical nadifloxacine– benzoyl peroxide and clindamycin– benzoyl peroxide in patients of acne vulgaris. Materials and Methods: 74 patients between 12 to 40 years having inflammatory and/or non–inflammatory lesions. Group 2 was prescribed nadifloxacin–benzoyl peroxide gel. There were 38 patients Group1 and 36 patients in Group 2. Results: A within group comparison of inflammatory lesion and non–inflammatory lesion count from baseline to different time points (4 and 8 weeks) showed a highly significant reduction of scores (P<0.0001). Nadifloxacine is effective, tolerable, safe and cost effective for mild to moderate facial acne. Conclusion: Its clinical effectiveness is comparable to clindamycin when used as add–on therapy to benzoyl peroxide.