A CROSS SECTIONAL STUDY OF CLINICAL PROFILE, BIOCHEMICAL & HORMONAL STUDIES OF POLYCYSTIC OVARIAN DISEASE .

Dr. Jayshree Awalekar; Dr. Chidanand Awalekar; Dr. M. H. Patwardhan

Volume : V, Issue : X, October - 2015

A CROSS SECTIONAL STUDY OF CLINICAL PROFILE, BIOCHEMICAL & HORMONAL STUDIES OF POLYCYSTIC OVARIAN DISEASE .

Dr. Jayshree Awalekar, Dr. Chidanand Awalekar, Dr. M. H. Patwardhan

Abstract :

 Polycystic ovarian disease (PCOD) is common endocrine disorder. Clinical, Hormonal & biochemical profile was studied in PCOD .Majority of young females are affected. Insulin resistance is main causative factor for all these consequences & morbidity. Along with hyperinsulinemia, dysfunction of hypothalamopituitoryadrenal axis is a key etiological factor in development of all manifestations of PCOD & cause hyperandrogenism(4,5). They present with irregular menses, infertility, obesity, Hirsutism, Acanthosis Nigricans etc.Investigations done are LH (Luteinizing Hormone), FSH (Follicle stimulating hormone) & Serum Insulin levels. Hormonal derangement & hirsutism was studied by LH/FSH Ratio, Resistance to insulin is diagnosed at HOMA–IR levels ≥6.8(26).Our study shows irregular menses in 62 % of PCOD cases, Hirsutism in 34%,Infertility in 40% case ,Acanthosis Nigricans in 86% of PCOD cases & in Acne 23%.Following manifestations of PCOD are also documented in our study. DM– 19% Hypertension in 4%, Cardiac disease–1%.Following observations were noted– BMI–>25 observed in 65 %patients, Waist/Hip Ratio– >0.8 is observed in 30%,HOMA Index was increases in 82% of PCOD cases.