A Fine Needle Aspiration Study Of Hepatocellular Carcinomas And Differentiation From Metastatic Adenocarcinoma.

Dr Ajit Nambiar; Dr Leena Naik

Volume : IX, Issue : II, February - 2019

A Fine Needle Aspiration Study Of Hepatocellular Carcinomas And Differentiation From Metastatic Adenocarcinoma.

Dr Ajit Nambiar, Dr Leena Naik

Abstract :

A retrospective study of USG/ CT scan guided fine needle aspiration cytology were performed on 71 cases of mass lesions in the liver. Of the 71 cases included over a period of 3 years , 31 were cases of hepatocellular carcinoma while 40 were cases of metastasis to the liver. The various cytological features studied included cell patterns, cell shape, nuclear and cytoplasmic features, bile and the presence or absence of normal hepatocytes in the background. The cytologically significant cytological criteria (p value <0.001) in diagnosis of hepatocellular carcinoma included trabecular/ arborescent pattern along with polygonal cells with central nuclei, intranuclear inclusions and granular cytoplasm. While key features for metastasis to liver include acinar or syncytial pattern, columnar/ cuboidal cells with normal hepatocytes in cords in the background. The cytopathologist when applying cytological criteria for diagnosis should take into account the clinical history, radiological studies and the biochemical reports