Volume : IX, Issue : I, January - 2019

A PROSPECTIVE OBSERVATIONAL STUDY ON ASSESSMENT OF CLINICAL OUTCOMES OF PROPHYLACTIC THERAPY IN MIGRAINE

Sk Afsar Pasha, Himaja S, Vaishnavi Ch, Manisha K, Yogitha J, Haribabu R, Sk Arif Pasha

Abstract :

Introduction: The goal of migraine treatment is to reduce the frequency, severity of migraine and to improve the quality of life in migraine patients. Hence, the study was aimed to assess the Clinical Outcomes in patients with Migraine taking different Prophylactic Anti Migraine drugs for a fixed duration of time along with adverse drug reactions associated with the therapy. Methodology: The study was aProspective Observational Study conducted in patients seeking treatment for migraine in a tertiary hospital in Guntur with from September 2017 to March 2018. The patients were divided into 2 groups (Group I: Amitriptyline and Propranolol and group II: Flunarizine and Propranolol) depending on the combinational drugs used for the prophylaxis. Migraine disability Assessment Scale (MIDAS) and Headache Impact Test (HIT–6) scores were used at the baseline and at 10–12 weeks after treatment and the clinical outcomes was assessed. Results: Of these 132 patients, 51 (38.63%) patients belongs to Group I and 81 (61.36%) belongs to Group II. The mean age of population of Group I was found to be 38.31±11.61 and Group II was 35.91±11.02. The baseline MIDAS score was 126.17±99.42 for group I and 100.72±85.42 in group II. The baseline HIT–6 score was 70.39±8.21 for group I and 69.08±11.46 in group II. Both MIDAS and HIT–6 scores significantly reduced after receiving treatment (p value <0.05). Group–II was more effective prophylactic therapy in migraine when compared to Group–I. In both the Groups some commonly observed Adverse Drug reactions were weight gain, sedation and dizziness. Conclusion:The baseline mean scores obtained improved after 10–12 weeks of interventional drug therapy concluding that the both Groups were effective in reducing the frequency and severity of migraine.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

A PROSPECTIVE OBSERVATIONAL STUDY ON ASSESSMENT OF CLINICAL OUTCOMES OF PROPHYLACTIC THERAPY IN MIGRAINE, SK Afsar Pasha, Himaja S, Vaishnavi Ch, Manisha K, Yogitha J, Haribabu R, SK Arif Pasha INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-1 | January-2019

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