A PROSPECTIVE STUDY OF EFFECT OF ANTIEPILEPTIC DRUGS ON SERUM VITAMIN D LEVELS IN PEDIATRIC EPILEPTIC PATIENTS.

Amir M. Bhat; Sheeraz A. Dar; Irshad A. Bhat; Bashir A. Charoo

Volume : IX, Issue : II, February - 2019

A PROSPECTIVE STUDY OF EFFECT OF ANTIEPILEPTIC DRUGS ON SERUM VITAMIN D LEVELS IN PEDIATRIC EPILEPTIC PATIENTS.

Amir M. Bhat, Sheeraz A. Dar, Irshad A. Bhat, Bashir A. Charoo

Abstract :

Background: Antiepileptic drug (AED) induced disturbances of bone metabolism are usually accompanied by a fall in the 25(OH)D level, hypocalcaemia, secondary hyperparathyroidism, and increased bone turn over with a decrease in bone density. Objectives: The objective of this study is to evaluate vitamin D status in epileptic children taking anticonvulsants. Method: All newly diagnosed seizure patients aged between 1 months to 16 years with no co morbid condition, who had not received therapeutic vitamin D doses in last 6 months and whose vitamin D level were greater than 20 ngs/ml at the time of enrolment in the study were included in study. Results: Out of 30 cases 13(43.3%) had decreased vitamin D levels to <20ng/dl where as in controls out of 30 only 4 (13.3%) had decreased vitamin D level to < 20ng/dl at the end of study. Conclusions: This study identifies significant risk of vitamin D deficiency in ambulant children with epilepsy on antiepileptic drugs.