Volume : VIII, Issue : VIII, August - 2018

A Prospective study of Inflammatory Response Following Laparoscopic and open Cholecystectomy

Dr Mrityunjai Kumar, Dr Ankur

Abstract :

Background: Surgical trauma induces immediate neuroendocrine, metabolic, and immunologic responses in the body, aimed at controlling tissue damage, combatting infection, and promoting processes to repair and restore damaged tissues through inflammatory and anti–inflammatory factors.   Aim: The aim of the study was to evaluate the inflammatory response to surgical trauma open and laparoscopic cholecystectomy.   Materials and Methods: The study was done from June 2017 to May 2018 in department of general surgery Jawaharlal Nehru medical college, Bhagalpur, Bihar. The study included 60 cases, divided into 2 groups. Group 1– 30 laparoscopic and Group 2– 30 open cholecystectomies. Bloodsamples were collected 2 hours preoperatively and at 4 and 24 hours post surgery. Blood was evaluated for the levels ofinterleukin–1β, interleukin–10, and tumor necrosis factor–alpha. Two groups were compared.   Results: The levels of interleukin–1β, interleukin–10,and tumor necrosis factor–alpha was significantly more inthe open cholecystectomy group at 4 hours. At the24th postoperative hour, the levels of all 3 cytokines werealso higher in the open cholecystectomy group.   Conclusion: The result of the present study confirms that open cholecystectomy causesmore significant stress response in the form of raised ILs and TNF levels as compared to laparoscopic cholecystectomy at 4 and 24 hours afterthe surgery. Hence the post–operative pain was lesser in laparoscopic cholecystectomy group patients.

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr Mrityunjai Kumar, Dr Ankur, A Prospective study of Inflammatory Response Following Laparoscopic and open Cholecystectomy, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-8 | August-2018

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