A RANDOMIZED CLINICAL STUDY TO DETERMINE THE EFFICACY OF NABUMETONE AND ACECLOFENAC IN OSTEOARTHRITIS PATIENTS USING IGADS

Dr. P. Jagadeesh; Dr. P. Vijayalakshmi

Volume : VIII, Issue : V, May - 2018

A RANDOMIZED CLINICAL STUDY TO DETERMINE THE EFFICACY OF NABUMETONE AND ACECLOFENAC IN OSTEOARTHRITIS PATIENTS USING IGADS

Dr. P. Jagadeesh, Dr. P. Vijayalakshmi

Abstract :

Background: Osteoarthritis (OA) is a common degenerative form of joint disease predominantly affecting the weight beå joints of the body. It is also the most common among all other types of arthritis and its treatment poses a huge financial burden to the society. It is caused by the eakdown and eventual loss of cartilage of one or more joints. OA frequently leads to chronic pain and disability and the chances of its occurrence increases with increasing age.

Aim and objectives: the present study was done 1) To study the efficacy of nabumetone and aceclofenac in patients with moderate to severe osteoarthritis of the knee. 2) To compare the efficacy of nabumetone and aceclofenac in patients with moderate to severe osteoarthritis of the knee. Materials and methods: A total of 68 patients were randomized into 2 treatment groups of which 34 patients were given nabumetone1000 mg tablet once a day orally and the other 34 patients were given aceclofenac 100 mg twice a day orally. The duration of treatment is 12 weeks during which the patients were instructed not to take any other drugs. Evaluation of of efficacy was done based on the assessment of clinical improvement in terms of pain intensity, joint swelling and tenderness, functional capacity and ability to flex the knee by Investigator Global Assessment of Disease Status (IGADS) scale at 12 weeks.

Results: Nabumetone as well as aceclofenac markedly, improved the clinical condition in the study population with 82.75% of patients showing fair to very well improvement in clinical outcome in the case of nabumetone. In the case of aceclofenac the improvement was 81.47%. p > 0.05, the result is statistically not significant.

Conclusion: The efficacy of nabumetone is similar to that of aceclofenac in patients with moderate to severe osteoarthritis of knee.