A Retrospective Study to Evaluate Association Between Thyroid Peroxidase Antibodies And Pregnancy Outcome

Dr Reeta Shukla; Dr. Meenakshi Devi; Dr. Anand Kumar

Volume : X, Issue : III, March - 2020

A Retrospective Study to Evaluate Association Between Thyroid Peroxidase Antibodies And Pregnancy Outcome

Dr Reeta Shukla, Dr. Meenakshi Devi, Dr. Anand Kumar

Abstract :

Aim: study was to compare pregnancy outcome in euthyroid women who were anti–TPO–Ab positive with those who were anti TPO–Ab negative. Design: observational study method : comprised 500 women in the age group of 18–35 years, having normal thyroid function test normotensive, nondiabetic, singleton pregnancy attending OPD SRN Hospital Allahabad and Kamala Nehru Hospital in Prayagraj November 16 – October 17, all euthyroid pregnancy, those were already in process of abortion and those aborted in our hospital. Anti TPO–Ab level of > 50 IU/ml were considered as anti TPO–Ab positive. Main outcome:– estimation of proportion of anti TPO–Ab in women attending OPD in hospital and comparison of maternal and neonatal out come in anti TPO– Ab Positive and anti TPO–Ab negative euthyroid women were done. RESULT:– increased rate of miscarriage (12.5 vs 2.39%) p <0.05, LBW ( 27.5 vs 5.217%) p < 0.05,and preterm birth (17.5 vs 3.4%) p < 0.05, in anti– TPO–Ab positive as compored to anti– TPO– Ab negative women. CONCLUSION– Study revealed anti–TPO– Ab is strongly associated with miscarriage, preterm birth irrespective of their gestational age, LBW is also significantly associated with anti–TPO–Ab positivity. However we did not find any correlation with other complication as found in studies by other authors.