A Simple and Economic Synthesis of 5–(aminomethyl)–4–(substituted  phenyl)–6–methyl–3,4–dihydropyrimidin–2(1H)–ones.

Rohinee R. Dharamkar; Dr. Y.K. Meshram

Volume : VII, Issue : VII, July - 2017

A Simple and Economic Synthesis of 5–(aminomethyl)–4–(substituted phenyl)–6–methyl–3,4–dihydropyrimidin–2(1H)–ones.

Rohinee R. Dharamkar, Dr. Y. K. Meshram

Abstract :

A Simple and Economic Synthesis of 5–(aminomethyl)–4–(substituted phenyl),6–methyl, 3,4–dihydropyrimidin–2(1H)–ones by using 5–amido–4–(substituted phenyl), 6–methyl, 3,4–dihydropyrimidin–2(1H)–ones and Lithium Aluminium Hydride in presence of completely dry THF. Lithium aluminium hydride has been found to be effective reducing agent. Different amides can be efficiently reduced with lithium aluminium hydride (LAH) to the corresponding Mannich bases.