Volume : V, Issue : II, February - 2015

A STUDY OF BIOCHEMICAL MARKERS IN ALCOHOLIC LIVER DISEASE

Y. Krishna Mohan, K. Venkateshwarlu, A. Padmavijayasree, Dvhs. Sharma, B. Vijayasaradhini, V. Satyanarayana

Abstract :

Chronic and excessive alcohol ingestion is one of the major causes of Liver diseases in the western world. Now alcohol consumption is increasing in modern India. Fatty Liver is present in 90% of chronic alcoholics. Alcohol is considered as a direct hepatotoxin. Progressive fiosis and cirrhosis, clinically presenting as end–stage liver disease are common outcomes in alcoholic Liver disease (ALD) patients. A variety of laboratory tests are available to assist in the progression and diagnosis of cirrhosis to end stage liver disease. The aim of this study is to identify potential novel biomarkers for progression of cirrhosis to end–stage liver cirrhosis.A total of 150 subjects were participated in this study.100 were diagnosed as alcoholic liver cirrhosis and 50 were normal health subjects. The biomarkers evaluated in this study included liver function indicators including serum albumin, total bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma–glutamyltransferase (GGT) and renal parameters (urea and creatinine). The AST,ALT,GGT,ALT/AST Ratio and Bilirubin are significantly elevated in alcoholic liver cirrhosis compared to healthy controls. Serum albumin is decreased in alcoholic liver disease patients than in healthy controls.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Y.Krishna Mohan, B. Naga Jyothi, M.Aparna, U. Sarada, K.Amarnath Reddy A Study of Biochemical Markers in Alcoholic Liver Cirrhosis Indian Journal of Applied Research, Vol.5, Issue : 2 February 2015

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