A STUDY OF BIOCHEMICAL PROFILE IN METABOLIC SYNDROME

Dr. Chelamkuri Gayathri; Dr. M.Venkateshwarlu

Volume : V, Issue : X, October - 2015

A STUDY OF BIOCHEMICAL PROFILE IN METABOLIC SYNDROME

Dr. Chelamkuri Gayathri, Dr. M. Venkateshwarlu

Abstract :

Metabolic Syndrome refers to a conglomeration of various interrelated cardio–metabolic risk factors that predispose to the development of Atherosclerotic Cardiovascular disease (ASCVD) and Type 2 Diabetes Mellitus. Aims and Objectives: The aim of the present study is to identify persons with metabolic syndrome using Modified NCEP ATP–III criteria and study their biochemical and anthropometric parameters and assess Insulin Resistance by simple indices like fasting serum Insulin, TG/ HDL–C and HOMA–IR values. Materials and Methods: The current study included a total of 100 participants divided into two groups Cases(n=50) and Controls (n=50) aged above 35 years from Departments of General Medicine, Government General Hospital, Kadapa. Each group, namely Cases and Controls, includes 25 males and 25 females. Participants with Cardiac, Hepatic and Renal impairments were excluded from the study. The biochemical and anthropometric profile of Cases were compared with those of Controls. Each subject was screened for the presence of metabolic syndrome based on the criteria set by modified NCEP ATP–III which required the presence of at least three risk factors. Results: The mean and S.D of serum total cholesterol, triglycerides, VLDL–C, LDL–C in controls are 168.2 ± 8.55, 136.72 ± 12.87, 27.38 ± 2.62, 91.78 ± 7.34 respectively as compared to 214.94 ± 20.94, 196.26 ± 21.56, 39.22 ± 4.32, 141.22 ± 20.16 in cases. The comparative data of HDL–C (mg/dL) of controls and cases (both the sexes separately) infers the mean and S.D of male controls is 45 ± 2.45 as compared to 31.96 ± 3.79 in cases. The corresponding data in females is 53.08 ± 1.96 in controls and 37.04 ± 4.89 in cases. The p–value is <0.0001 in both groups, highly significant. The mean and S.D. of fasting serum glucose in controls is 87.48 ± 6.86 as compared to 140.37 ± 10.01 in diabetics and 92.3 ± 5.90 in non diabetics. The p–value is <0.0001(highly significant) in those with history of type 2 DM. The mean and S.D. of HOMA–IR of controls is 1.47 ± 0.33, the mean and S.D. of HOMA–IR of cases with history of type2 DM is 9.99 ± 1.41 as compared to 3.78 ± 0.51 in those without history of type2 DM. The p–value in both the groups is < 0.0001, which is considered highly significant Conclusion: Metabolic syndrome is a constellation of lipid and non lipid risk factors of metabolic origin. The clinical relevance of metabolic syndrome is related to its role in the development of cardiovascular disease. The best reason to consider the diagnosis of metabolic syndrome is to identify obese people who are most likely to be benefited from aggressive efforts. A focus on metabolic syndrome will encourage public health efforts to give more priority to the promotion of weight control and physical activities in their societies. Simple and economical measures like Life Style Modifications (LSM) and lipid lowering therapy may reduce the burden cardiovascular morbidity and mortality.