A STUDY OF CORRELATION BETWEEN GLYCOSYLATED HAEMOGLOBIN (HbA1c) AND FASTING LIPID PROFILE (FLP) IN DIABETIC FOOT WOUND HEALING

Mohammed Nadeem Nazim; M.S.Moosabba

Volume : VII, Issue : VIII, August - 2017

A STUDY OF CORRELATION BETWEEN GLYCOSYLATED HAEMOGLOBIN (HbA1c) AND FASTING LIPID PROFILE (FLP) IN DIABETIC FOOT WOUND HEALING

Mohammed Nadeem Nazim, M. S. Moosabba

Abstract :

INTRODUCTION– Foot infections in persons with diabetes are an increasingly common problem and are associated with potentially serious sequelae. Diabetic foot complications continue to be the main reason for diabetes–related hospitalization and lower extremity amputations.While there are no guidelines to use HbA1c as a screening tool, physicians consider its elevated value as an indicator of diabetes mellitus. METHODOLOGY–105 patients between the age of 30–70 years who were diabetics with foot ulcers of maximum dimension 10cms x 10cms where included in the study. Each ulcer was studied for a period of 30 days. Diabetics with foot ulcers along with peripheral vascular disease/ underlying osteomyelitis and gangrene were excluded from the study. . In this study, we observed the rate of wound healing in relation to HbA1c and FLP levels. Data was analysed using Karl Pearson correlation between the variables and the rate of healing and their levels of significance.

RESULTS– The statistical analysis showed the mean value of the HbA1c (%) for the patients with Diabetic foot ulcer was 9.89%. in addition, 61.9% (n=65) were males with the mean age being 54.22 ± 9.580 (Mean±SD(Standard Deviation)). Patients with higher HbA1c levels took longer for wound healing when compared to patients with lower HbA1c levels. The average number of days taken for wound healing was 17.52 ± 6.048 (Mean±SD). Pearson’s correlation test showed that the values of HbA1c have highly positive correlation with the number of days when compared to TC (Total Cholesterol), HDL(High Density Lipoproteins), LDL(Low density Lipoproteins), TG(Triglycerides) and VLDL(Very Low Density Lipoproteins). In the contrary, TC level contain highly negative correlation with the number of days (P Value=0.063).

CONCLUSION: With and increase in HbA1c levels, the wound took longer to heal and also levels of Cholesterol,LDL,TG were elevated in more than 60% of the patients . In this study, HbA1c was found to be a better predictor of diabetic wound healing.