A Study of Diagnostic Utility of Ischemia Modified  Albumin in Cerebrovascular Accidents

Dr. Bhumi H. Dalsania; Dr. Dharmik S. Patel; Dr. Bhakti N. Gami; Dr. N. Haridas

Volume : III, Issue : VI, June - 2013

A Study of Diagnostic Utility of Ischemia Modified Albumin in Cerebrovascular Accidents

Dr. Bhumi H. Dalsania, Dr. Dharmik S. Patel, Dr. Bhakti N. Gami, Dr. N. Haridas

Abstract :

Background: The absence of a widely available and sensitive diagnostic test, acute cereal ischemia remains a significant limitation in the diagnosis and management of stroke. Computed Tomography (CT) scanning and MRI are may be normal in early phase or not feasible every time in developing country like India. Ischemia Modified Albumin (IMA) is a marker for ischemia. Pathophysiology of stroke also involved ischemia. Hence objective of this study is to evaluate diagnostic utility of IMA in cereo–vascular stroke. Method: This cross sectional type of study consists of 100 subjects, 35 ischemic stroke, 15 hemorrhagic stroke (definitive diagnosis based on radiological images) and 50 as control. Blood samples obtained within 6 hours of presentation were analysed for IMA by albumin cobalt binding assay. Result: IMA concentrations were 0.410 ± 0.0478 absorbance unit (ABSU) in ischemic stroke, 0.319 ± 0.0632 ABSU in hemorrhagic stroke and 0.240 ± 0.0363 ABSU in control group. IMA concentrations were statistically higher (p < 0.0001) among stroke group as compare to control and there was also statistical difference (p < 0.001) of IMA concentrations between ischemic stroke and hemorrhagic stroke. At cut off value of 0.297 ABSU (by ROC curve), IMA have diagnostic sensitivity of 94% and specificity of 90%. Conclusion: It is found that IMA has potential role in diagnosis of acute ischemia in cereovascular accidents as well as it also differentiates types of stroke. So, Clinical diagnosis when supplemented by IMA estimation may be useful for confirmation of the diagnosis.