Volume : VII, Issue : XI, November - 2017

A study of effects of anticholinergic drugs on thermoregulation in paediatric patients undergoing ambulatory anaesthesia with ketamine

Dr. Kiran Janwe, Dr. Abhay Rathod, Dr. Puja Deshpande, Dr. Yogesh Salphale

Abstract :

 

Aims and objectives: A randomized, double–blind, prospective study to evaluate the effect of anticholinergic drugs on thermoregulation in paediatric patients undergoing ambulatory anaesthesia with ketamine.

Methodology: Patients were randomized to receive either 0.005 mg/kg glycopyrrolate or the equivalent volume of normal saline (placebo) at 30 min before ketamine anaesthesia. Body temperature was measured tympanically at baseline and at 0, 30, 60 and 90 min postoperatively. The quantity of saliva prodiced during surgery and incidence of fever were recorded.

Results: Body temperature was significantly higher in the glycopyrrolate group (n = 42) than the placebo group (n = 42) at 30, 60 and 90 min after surgery, and higher than baseline at 0, 30, 60 and 90 min after surgery. In the placebo group, body temperature was significantly higher than baseline at 0 and 30 min after surgery. Saliva secretion was significantly lower in the glycopyrrolate group than the placebo group.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr. Kiran Janwe, Dr. Abhay Rathod, Dr. Puja Deshpande, Dr. Yogesh Salphale, A study of effects of anticholinergic drugs on thermoregulation in paediatric patients undergoing ambulatory anaesthesia with ketamine, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-7 | Issue-11 | November-2017

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