Volume : VII, Issue : X, October - 2017

A Study of estrogen as an endogenous diabetogenic factor in diabetic patients

Dr N P Suryawanshi, Dr K A Deshpande, Dr R R Gadpal

Abstract :

 Aims & Objectives : 1) To estimate serum levels of estrogen in 30 normal healthy control subjects & 30 Type 1 & Type 2 Diabetes Mellitus (DM) patients.  2) To assess statistically whether estrogen is a most suitable parameter for prognosis & treatment of the DM patients.  Materials & Methods : The present study was carried out in Department of Biochemistry, GMCH, Nagpur from May 2003 to May 2005.  About 60 diabetic patients aged between 15–80 years were selected from diabetic OPD of GMCH, Nagpur under dept. of  Medicine after written informed consent & after satisfying all inclusion criterias.  5 ml of fasting venous blood was withdrawn from each control & patient using a disposable syringe & needle under all aseptic precautions.  The blood obtained thus was collected in a sterile bulb & allowed to clot at room temperature for at least 20 minutes.  After this serum was separated by centrifugation.  The serum thus obtained was used for the following estimations without further delay.  All the water used in the following estimations was distilled & deionised & all reagents used were of analytical grade.  The study subjects were classified into 3 groups : 1) Group I 30, controls, 2) Group II 30, type 1 DM patients, 3) Group III 30, type 2 DM patients.  Serum estrogen levels in patients & controls were estimated using ELISA technique.  Results : It is evident from the present study that levels of estrogen in female patients of Type 1 & Type 2 DM patients were significantly elevated as compared to controls.  Conclusion: We may say that the determination of changes in estrogen can be considered as a valuable endogenous diabetogenic factor which result in abnormal glucose metabolism.   

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr N P Suryawanshi, Dr K A Deshpande, Dr R R Gadpal, A Study of estrogen as an endogenous diabetogenic factor in diabetic patients, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-7 | Issue-10 | October-2017

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