Volume : IX, Issue : I, January - 2019

A STUDY OF GGT IN ALCOHOLICS WITH AND WITHOUT LIVER DISEASE

Dr. R. Rama Krishnam Raju, Dr. Amritha Thoomati

Abstract :

Introduction– Alcohol abuse and alcohol–induced liver disease represent major mortality risks. Gamma–glutamyltransferase (GGT) is a highly sensitive indicator of heavy drinking and fatty liver, the most common pathological condition associated with alcohol abuse. Although challenged by some as too sensitive and too non–specific for diagnostic purposes, it has been endorsed for use in alcoholic treatment programs. In combination with SGOT, SGPT, alkaline phosphatase and HDL, its value is considerably enhanced. Objectives– The aim of the present study is to assess the level of GGT and Biochemical liver function tests in alcoholics as biological markers and to find out the usefulness of these tests in alcoholics with and without liver abnormality as determined by ultrasonographic changes. Methods– 60 male patients aged 15–45 years attending the psychiatry out patient department who fulfilled DSM 5 criteria for alcohol dependence were selected. Blood sample was analysed for determining Hb%, Total WBC Count, Differential WBC Count, and Liver Function Tests (S.Bilirubin, S.Proteins, AST, ALT, GGT, Alkaline Phosphatase, GGT). the patients were further screened for liver abnormalities by ultrasonography of abdomen. Results– The current study showed a significant increase in levels of GGT in 78.4% and S. Bilirubin (67.6%), AST (66.1%), ALT (47.6%) and ALP (46%) patients. In cases of Group I (with liver abnormality) values of GGT, AST, and ALT were statistically higher than cases of Group II (without liver abnormality). Though literature supports that serum GGT determination was far more sensitive indicator of hepatic involvement than the transaminases or alkaline phosphatase, in the present study AST and ALT were also sensitive enough.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

A STUDY OF GGT IN ALCOHOLICS WITH AND WITHOUT LIVER DISEASE, Dr. R. Rama Krishnam Raju, Dr. Amritha Thoomati INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-1 | January-2019

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