Volume : IX, Issue : IV, April - 2019

A STUDY OF HEMATOLOGICAL ABNORMALITIES IN CHRONIC LIVER DISEASE

Dr. Viney Sambyal, Dr. Deepak Bharti

Abstract :

Aim: To assess the hematological profile of patients with chronic liver disease and their correlation in patients with GI Bleed. Materials and Methods: To assess the hematological abnormalities in chronic liver disease, a cross sectional analytical study was conducted, all patients taken up for the study were evaluated in detail. Oral consent was obtained for clinical examination and lab investigations. Written consent was obtained for procedures such paracentesis, Upper GI endoscopy and viral marker studies. Observation & Data Analysis: A descriptive study to assess the hematological abnormalities in chronic liver disease was conducted in department of Medicine GMC Jammu from January 2016 to December 2016. 546 patients with chronic liver disease were taken for the study; this included 430 males (78.8%) and 116 females (21.2 %). The age range was from 20 to 80 yrs. The average age of the patients in the study was 48 yrs. 38.4 % of the patients were between 41 and 50 years. 54.7% of the patients had alcoholic cirrhosis. The aetiology of chronic liver disease could not be determined in 16.7 % of cases but all of them had clinical and radiological features of cirrhosis. 86(15.7%) patients had Hepatitis B and 56(10.3%) had Hepatitis C. Results: 48.7 % of the patients had thrombocytopenia (<1.5 lakh). The average platelet count of patients who experienced an upper GI bleed was 92000 vs. 1.2 lakh in patients without a GI bleed. 26 patients (4.8%) had a prolonged INR more than 2.5. Conclusion: Many conclusive results regarding the hematological abnormalities in chronic liver disease were obtained with this limited study involving 546 patients with cirrhosis ⇒ 48.7 % of patients had thrombocytopenia. ⇒ The average platelet count of patients with an upper GI bleed was 92000 compared to 1.2 lakh to those without an upper GI bleed; suggesting other factors such functional platelet defects may play a role as well. This need to be confirmed with platelet functional studies⇒ The PT–INR was elevated in 85.7 % of patients.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

A STUDY OF HEMATOLOGICAL ABNORMALITIES IN CHRONIC LIVER DISEASE, Dr.Viney Sambyal, Dr.Deepak Bharti INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-4 | April-2019

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