Volume : X, Issue : II, February - 2020

A STUDY OF HOMOCYSTEINE LEVEL AS A RISK FACTOR FOR RECURRENT EARLY PREGNANCY LOSS

Nagasutha D, Annapoorani R

Abstract :

This study is a hospital based prospective study in a teaching hospital. AIMS AND OBJECTIVES: 1.To estimate the relative risk of recurrent early pregnancy loss for different total plasma homocysteine concentrations. 2.To study the incidence of recurrent pregnancy loss in the study population. 3.To estimate the relative risk of recurrent early pregnancy loss for different total plasma homocysteine concentrations and compare the levels with those of healthy controls. 4.To study coexisting anomalies,if any are present. MATERIAL AND METHODS: 60 Patients attending genetic op and antenatal clinic with recurrent miscarriage (>2 pregnancy losses ) were enrolled in the study as cases. The control group consisted of women who had delivered at least one live born infant and no spontaneous abortions and comparable for age, geographical area, and social class. 30 antenatal women from antenatal op taken as control.All pregnancies to be confirmed by a positive urinary hCG test or ultrasound imaging.Fasting Blood sample taken after obtaining consent from the patient.All patients started on routine folic acids.For those with elevated homocysteine B6 and B12 added.Pedigree analysis of the patients was done in detail and results analysed. CONCLUSION: Our study has an incidence of recurrent pregnancy loss of 1% in our study population. The study of our 60 RPL cases showed 6 patients with hyperhomocysteinemia which has a 10% rate of occurrence. Our odds ratio with 3.22 indicates that hyperhomocysteinemia has an increased rate of occurrence among the people with RPL with correlates well with other studies. Therapeutic normalization of homocysteine in supplementation with folic acid B6,B12 in 4 out of 7 indicates the management options that can be tried. Our study indicates that there is no correlation of age with hyperhomocysteinemia.Primary aborters have a higher incidence of hyperhomocysteinemia when compared with secondary aborters. As suggested by our case report, therapeutic normalization of hyperhomocysteinemia might lead to metabolic restoration, which may favor a successful pregnancy outcome

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Article: Download PDF    DOI : 10.36106/ijar  

Cite This Article:

A STUDY OF HOMOCYSTEINE LEVEL AS A RISK FACTOR FOR RECURRENT EARLY PREGNANCY LOSS, Nagasutha D, Annapoorani R INDIAN JOURNAL OF APPLIED RESEARCH : Volume-10 | Issue-2 | February-2020

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