Volume : VII, Issue : X, October - 2017

A STUDY OF QTd AS AN INDICATOR OF CARDIAC AUTONOMIC NEUROPATHY IN TYPE 2 DIABETES MELLITUS

Vijayakumari Vrinda, Victor Theophilus Premkumar

Abstract :

 

CONTEXT

Cardiac Autonomic Neuropathy (CAN) is often   

overlooked both in diagnosis and treatment simply because there is no widely accepted single approach to its diagnosis. Currently, Cardiovascular autonomic reflex tests (CART) are the gold standard for diagnosing CAN in persons with DM .It include four tests: (i)heart rate variation to deep eathing (ii) heart rate variation to

Valsalva, (iii.)heart rate response to standing (30:15), and (iv) orthostatic hypotension.

But these tests  are cumbersome and not easy to perform in every patient.  Therefore, there is  a need of simple, non–invasive bed side test to detect early autonomic involvement in diabetes.

 

AIM OF THE STUDY

  To determine QTc maximum, QTc mean , QTc minimum QTc

dispersion in Type2 diabetic  patients.

  Comparison of QTc maximum, QTc minimum, QTc

dispersion, QTc mean in both study group and control group.

  To study the significance of QTd as an indicator of CAN in Type 2 Diabetes mellitus.

 

SETTINGS AND DESIGN

Analytical Case Control Study.

 

MATERIALS AND METHODS

The study was conducted among patients from General

Medicine wards  of  Government Rajaji Hospital, Madurai during the period of  Feuary 2016 to July 2016. The study included 100 cases of diabetes and 100 age and sex matched controls.  Subjects believed to fulfill all eligibility criteria, and none of the exclusion criteria were included  in the study.

 

STATISTICAL ANALYSIS

One way ANOVA, Pearson correlation and Chi square test.

 

RESULTS

The average age for study group was 55 years. Among the 100 patients studied 55 were males and 45 females . Among the cases studied 62 had CAN .Of these 62, 44 had Grade 2(severe) CAN, 18 had Grade1(early) CAN .Mean heart rate was found to be high in diabetic patients compared to controls .Among the cases the heart rate was higher in those with severe CAN . QT mean ,QT minimum, QT maximum, QT dispersion was significantly more in patients with CAN than those without CAN and controls. Among those with CAN these were found to be significantly more in patients with Grade 2 CAN than those with Grade 1 CAN.

 

CONCLUSIONS

Diabetics with CAN had significantly higher QTc mean, QTc maximum ,QTc minimum, QTc dispersion values compared to diabetics without CAN

and controls . 

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Vijayakumari Vrinda, Victor Theophilus Premkumar, A STUDY OF QTd AS AN INDICATOR OF CARDIAC AUTONOMIC NEUROPATHY IN TYPE 2 DIABETES MELLITUS, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-7 | Issue-10 | October-2017

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